Of Mice and Men: Bone-cells and Memory Loss Reversal


Columbia University Medical Center (CUMC) recently announced ground-breaking results regarding a hormone (osteocalcin) made by bone-cells, which has the potential of improving age-related memory loss. Published in August 2017 in the Journal of Experimental Medicine, CUMC's research team found that memory loss could be reversed in mice by boosting their blood levels of osteocalcin  (a hormone made by the same cells that create bones, and which levels decline with age in both mice and humans). The hormone then travels to the brain's memory center, where it strengthens neurones. The researchers also identified a possible target in the brain -- a receptor of osteocalcin -- which, with time and more research, would allow new possible treatments for age-related cognitive decline. 

The solution for age-related memory loss reversal in mice (and in people!) is therefore to give them an extra dose of osteocalcin.  A natural way of maintaining your osteocalcin levels up is to practice weight-bearing exercises, such as walking weight training, hiking, jogging, climbing stairs, tennis, and dancing. Start walking to remember !